Bacterial Virulence Factor Analysis Service
Profiling of virulence factors and pathogenicity islands.
Virulence analysis looks for genes that help bacteria cause disease, such as toxins, adhesins, secretion systems and iron-uptake systems. It also predicts the overall potential of the strain to be pathogenic in humans.
For beneficial strains the question is the reverse: showing that a probiotic or industrial strain lacks harmful virulence genes is a key part of a safety dossier.
What you receive
- Table of virulence-associated genes with identity and coverage
- Grouping by function: toxins, adhesion, invasion, secretion, iron acquisition
- Pathogenicity prediction with PathogenFinder2
- Genomic islands and clusters where several virulence genes sit together
- Interpretation in the context of the species and your application
How we do it
- 1
Gene screening
Predicted proteins are compared with curated databases of known virulence factors.
- 2
Pathogenicity prediction
PathogenFinder2 estimates the strain's potential to be a human pathogen.
- 3
Context
We check whether virulence genes cluster in islands or sit near mobile elements.
- 4
Interpretation
Results are weighed against what is normal for the species.
When you need it
- Safety assessment of probiotic, food and industrial strains
- Comparing virulence gene content between isolates
- Background for pathogenesis research
Questions
My probiotic has a hit to a 'virulence' gene. Is it unsafe?
Not necessarily. Many genes in virulence databases, such as adhesins, are also found in harmless strains. The report explains each hit in context.
Other services
- Whole Genome Analysis
- Genome Assembly
- Genome Annotation
- Species Identification
- ANI Analysis
- AMR Analysis
- Plasmid Analysis
- Mobile Genetic Elements
- Secondary Metabolite Analysis
- CAZyme Annotation
- Functional Annotation
- Pathway Analysis
- Comparative Genomics
- Genome Visualization
- Publication-Ready Reports
- Scientific Consultation
For Research Use Only. BacSeq Analytics provides bioinformatics analysis and interpretation services for microbial genomic research. The reports are intended for research and investigational purposes only and are not intended for clinical diagnosis.
Ready to turn your genome data into insight?
Get a highlight report within 72 hours. Share your project and our bioinformatics team will respond within one business day.