Service

Functional Annotation of Bacterial Genomes: KEGG and GO

Pathway, KEGG and GO functional characterisation.

Functional annotation assigns genes to standard categories so you can see, at a glance, what your strain is capable of. KEGG orthology links genes to pathways, and Gene Ontology (GO) terms describe their roles.

This makes it easy to compare strains and to find genes for specific traits, such as stress tolerance, vitamin synthesis or bile salt hydrolysis.

What you receive

  • KEGG orthology (KO) assignments for each gene
  • Summary of genes by KEGG category
  • GO term and RAST subsystem summaries
  • Highlighted genes for traits relevant to your study

How we do it

  1. 1

    KEGG mapping

    BlastKOALA assigns KEGG orthology numbers to predicted proteins.

  2. 2

    Category summaries

    Genes are grouped by KEGG, GO and RAST categories.

  3. 3

    Trait search

    We look for genes linked to traits you care about.

When you need it

  • Describing the functional potential of a new strain
  • Finding genes behind a trait seen in the lab
  • Comparing functional profiles between strains

Questions

How is this different from genome annotation?

Genome annotation finds genes and names them. Functional annotation places them into standard categories and pathways so they can be summarised and compared.

Further reading

Comparative GenomicsPangenome Analysis Explained: Core, Accessory and Unique GenesFunctional AnnotationCAZyme Analysis with dbCAN: What It Reveals About Probiotic and Industrial Strains

Other services

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For Research Use Only. BacSeq Analytics provides bioinformatics analysis and interpretation services for microbial genomic research. The reports are intended for research and investigational purposes only and are not intended for clinical diagnosis.

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